2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
- Product Name
- 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
- CAS No.
- 852391-19-6
- Chemical Name
- 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
- Synonyms
- Necrostatin 2;Necroptotic Inhibitor;Necrostatin 2 R-isomer;MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR;(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
- CBNumber
- CB52626148
- Molecular Formula
- C13H12ClN3O2
- Formula Weight
- 277.71
- MOL File
- 852391-19-6.mol
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Property
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 8.48±0.70(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 11657
- Product name
- Necrostatin-2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 11657
- Product name
- Necrostatin-2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 11657
- Product name
- Necrostatin-2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- A3652
- Product name
- Necrostatin2
- Packaging
- 5mg
- Price
- $273
- Updated
- 2021/12/16
- Product number
- 6577CS
- Product name
- (5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione
- Packaging
- 10mg
- Price
- $345
- Updated
- 2021/12/16
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Chemical Properties,Usage,Production
Biological Activity
necrostatin 2 (nec-2) is a novel and potent necroptosis inhibitor with ec50 of 50 nm. it is an analog of necrostatin 1 (nec-1).necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.nec-2 is efficacious in an animal model of ischemic stroke. many necroptosis inhibitor derivatives are designed for researchers. there is limited record for nec-2, but some reports are related with other necrostatins. nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase rip1 in vitro.
target
RIPK2
References
[1]. teng x, keys h, jeevanandam a, structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. bioorg med chem lett. 2007 dec 15;17(24):6836-40.
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Suppliers
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